Retningslinjer for antitrombotisk behandling og profylakse (2013, under oppdatering)

Published by Per Olav Vandvik on Oct 12, 2016

Disclaimer

Norwegian Guidelines for Antithrombotic Therapy and Thromboprofylaxis: An adaption and update of Antithrombotic Therapy and the Prevention of Thrombosis, 9th Edition: American College of Chest Physicians Evidence-based Guidelines has been produced with permission from the American College of Chest Physicians (“ACCP”), which is the owner of CHEST and the Antithrombotic Therapy and the Prevention of Thrombosis, 9th Edition: American College of Chest Physicians Evidence-based Guidelines. ACCP and its officers, regents, executive committee members, members, related entities, employees, representatives and other agents (collectively, “ACCP Parties”) played no role in the translation of Norwegian Guidelines for Antithrombotic Therapy and Thromboprofylaxis: An adaption and update of Antithrombotic Therapy and the Prevention of Thrombosis, 9th Edition: American College of Chest Physicians Evidence-based Guidelines from English into Norwegian. The ACCP Parties are not responsible in any capacity for, do not warrant and expressly disclaim all liability for, any content whatsoever in this publication and the use or reliance on any such content, and for the accuracy of the translation of the content, all such responsibility being solely that of the Norwegian Medical Association and the authors as the case may be. Furthermore, the content should not be considered medical advice and is not intended to replace consultation with a qualified medical professional. Under no circumstances shall any of the ACCP Parties be liable for any DIRECT, INDIRECT, INCIDENTAL, SPECIAL or CONSEQUENTIAL DAMAGES, or LOST PROFITS that result, directly or indirectly, from the disclosure or use of any of the content of the Guidelines adapted for dissemination in the MAGIC platform, regardless of legal theory.

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Abstract

Language

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PICOS

PICO 1.1

Population
Høy kardiovaskulær risiko (i henhold til NORRISK) Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.1

Population
Proksimal DVT i underekstremitet på antikoagulasjonsbehandling
Intervention
Vena cava filter
Comparator
Ingen filter
Outcomes

PICO 1.1

Population
Akutt iskemisk slag
Intervention
Iv rt-PA < 3timer
Comparator
Ingen trombolyse
Outcomes

PICO 1.1

Population
Moderat kardiovaskulær risiko (i henhold til NORRISK) Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Placebo D015990,
Intervention
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Placebo D015990,
Comparator
Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Placebo D015990,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Placebo D015990,

PICO 1.1

Population
Warfarinbruk perioperativt Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,
Intervention
Stopp >5 dager preoperativt Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,
Comparator
Stopp < 5 dager preoperativt Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,
Outcomes
Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,

PICO 1.1

Population
Oppstartsdose med warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, High dose 261829003, Low dose 262459003,
Intervention
10 mg Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, High dose 261829003, Low dose 262459003,
Comparator
5 mg Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, High dose 261829003, Low dose 262459003,
Outcomes
Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, High dose 261829003, Low dose 262459003,

PICO 1.1

Population
Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 0 Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,
Intervention
Warfarin Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,
Comparator
Ingen behandling Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,
Outcomes
Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859,

PICO 1.1

Population
Inneliggende indremedisinske pasienter med lav risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Profylakse (UFH, LMWH, Fondaparinuks) LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Placebo/ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.1

Population
Tromboseprofylakse hos pasienter med lav risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.2

Population
Moderat kardiovaskulær risiko (i henhold til NORRISK) Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.2

Population
Akutt iskemisk slag
Intervention
Iv rt-PA 3-4.5 timer
Comparator
Ingen trombolyse
Outcomes

PICO 1.2

Population
Lav kardiovaskulær risiko (i henhold til NORRISK) Aspirin 387458008, Aspirin B01 AC06, Aspirin D001241, Aspirin 1191, Placebo D015990,
Intervention
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin D001241, Aspirin 1191, Placebo D015990,
Comparator
Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin D001241, Aspirin 1191, Placebo D015990,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin D001241, Aspirin 1191, Placebo D015990,

PICO 1.2

Population
Overlapping mellom warfarin og LMWH Warfarin 372756006, LMWH 87233003, LMWH B01A B, Warfarin B01A A03, Warfarin 11289, LMWH D006495, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Intervention
Tidlig oppstart warfarin Warfarin 372756006, LMWH 87233003, LMWH B01A B, Warfarin B01A A03, Warfarin 11289, LMWH D006495, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Comparator
Sen oppstart warfarin Warfarin 372756006, LMWH 87233003, LMWH B01A B, Warfarin B01A A03, Warfarin 11289, LMWH D006495, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Outcomes
Warfarin 372756006, LMWH 87233003, LMWH B01A B, Warfarin B01A A03, Warfarin 11289, LMWH D006495, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 1.2

Population
Atrieflimmer og moderat risiko for slag: CHA2DS2-VASc 1 Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Intervention
Warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Comparator
Ingen behandling Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Outcomes
Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 1.2

Population
Inneliggende indremedisinske pasienter med høy risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Profylakse (UFH, LMWH, Fondaparinuks) LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Placebo/ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.2

Population
Tromboseprofylakse hos pasienter med lav risiko
Intervention
Kompresjonsstrømper
Comparator
Ingen behandling
Outcomes

PICO 1.3

Population
Akutt iskemisk slag
Intervention
Iv rt-PA >4.5 timer
Comparator
Ingen trombolyse
Outcomes

PICO 1.3

Population
Høy kardiovaskulær risiko (i henhold til NORRISK) Aspirin B01 AC06, , Aspirin 1191, Aspirin D001241,
Intervention
ASA Aspirin B01 AC06, , Aspirin 1191, Aspirin D001241,
Comparator
Ingen behandling Aspirin B01 AC06, , Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin B01 AC06, , Aspirin 1191, Aspirin D001241,

PICO 1.3

Population
Pasienter med lav tromboserisiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
"Bridging" med UFH/LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen "bridging" LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.3

Population
Farmakogenetisk testing før oppstart warfarin
Intervention
Dosering basert på genetisk testing
Comparator
Standard dosering
Outcomes

PICO 1.3

Population
Atrieflimmer og høy risiko for slag: CHA2DS2-VASc 2 eller høyere Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Intervention
Warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Comparator
Ingen behandling Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Outcomes
Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 1.3

Population
Inneliggende indremedisinske pasienter med lav risiko
Intervention
Kompresjonsstrømper
Comparator
Ingen behandling
Outcomes

PICO 1.3

Population
Tromboseprofylakse hos pasienter med moderat risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.4

Population
Akutt iskemisk slag
Intervention
IA trombolyse
Comparator
Ingen trombolyse
Outcomes

PICO 1.4

Population
Tannprosedyre Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Intervention
Warfarin + lokal hemostatisk medikament Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Comparator
Stopp warfarin 2-3 dager preoperativt Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Outcomes
Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 1.4

Population
Hyppighet av INR-kontroll
Intervention
INR-kontroll > 4 uker
Comparator
INR-kontroll hver 4. uke
Outcomes

PICO 1.4

Population
Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 0 Rivaroxiban B01A X06, Apixaban B01A F02, Dabigatran B01A E07, Dabigatran 1037042, Rivaroxiban C503223, Apixaban C522181, Dabigatran C554682, Warfarin D014859, Warfarin 11289, Warfarin B01A A03, LMWH 87233003,
Intervention
Nye perorale antikoagulantia Rivaroxiban B01A X06, Apixaban B01A F02, Dabigatran B01A E07, Dabigatran 1037042, Rivaroxiban C503223, Apixaban C522181, Dabigatran C554682, Warfarin D014859, Warfarin 11289, Warfarin B01A A03, LMWH 87233003,
Comparator
Warfarin Rivaroxiban B01A X06, Apixaban B01A F02, Dabigatran B01A E07, Dabigatran 1037042, Rivaroxiban C503223, Apixaban C522181, Dabigatran C554682, Warfarin D014859, Warfarin 11289, Warfarin B01A A03, LMWH 87233003,
Outcomes
Rivaroxiban B01A X06, Apixaban B01A F02, Dabigatran B01A E07, Dabigatran 1037042, Rivaroxiban C503223, Apixaban C522181, Dabigatran C554682, Warfarin D014859, Warfarin 11289, Warfarin B01A A03, LMWH 87233003,

PICO 1.4

Population
Inneliggende indremedisinske pasienter med høy risiko
Intervention
Kompresjonsstrømper
Comparator
Ingen behandling
Outcomes

PICO 1.4

Population
Tromboseprofylakse hos pasienter med høy risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.5

Population
Akutt iskemisk slag
Intervention
IV + IA trombolyse
Comparator
IV trombolyse
Outcomes

PICO 1.5

Population
Vitamin K supplement til pasienter på warfarin
Intervention
Vitamin K supplement
Comparator
Ingen supplement
Outcomes

PICO 1.5

Population
Atrieflimmer og moderat risiko for slag: CHA2DS2-VASc 1 Dabigatran B01A E07, Apixaban B01A F02, Rivaroxiban B01A X06, Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859, Dabigatran C554682, Apixaban C522181, Rivaroxiban C503223, Dabigatran 1037042,
Intervention
Nye perorale antikoagulantia Dabigatran B01A E07, Apixaban B01A F02, Rivaroxiban B01A X06, Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859, Dabigatran C554682, Apixaban C522181, Rivaroxiban C503223, Dabigatran 1037042,
Comparator
Warfarin Dabigatran B01A E07, Apixaban B01A F02, Rivaroxiban B01A X06, Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859, Dabigatran C554682, Apixaban C522181, Rivaroxiban C503223, Dabigatran 1037042,
Outcomes
Dabigatran B01A E07, Apixaban B01A F02, Rivaroxiban B01A X06, Warfarin B01A A03, Warfarin 372756006, Warfarin 11289, Warfarin D014859, Dabigatran C554682, Apixaban C522181, Rivaroxiban C503223, Dabigatran 1037042,

PICO 1.5

Population
Inneliggende pasienter med redusert mobilitet
Intervention
Forlenget profylakse etter utskrivelse
Comparator
Standard profylakse
Outcomes

PICO 1.5

Population
Tromboseprofylakse hos pasienter med moderat risiko
Intervention
Kompresjonsstrømper
Comparator
Ingen behandling
Outcomes

PICO 1.6

Population
Akutt iskemisk slag
Intervention
Mekanisk trombektomi
Comparator
Standard medikamentell behandling
Outcomes

PICO 1.6

Population
Hjemmemåling av INR
Intervention
Hjemmemåling
Comparator
Standard testing på laboratorium
Outcomes

PICO 1.6

Population
Atrieflimmer og høy risiko for slag: CHA2DS2-VASc 2 eller høyere Dabigatran B01A E07, Rivaroxiban B01A X06, Apixaban B01A F02, Warfarin B01A A03, Apixaban C522181, Rivaroxiban C503223, Dabigatran C554682, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Dabigatran 1037042,
Intervention
Nye perorale antikoagulantia Dabigatran B01A E07, Rivaroxiban B01A X06, Apixaban B01A F02, Warfarin B01A A03, Apixaban C522181, Rivaroxiban C503223, Dabigatran C554682, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Dabigatran 1037042,
Comparator
Warfarin Dabigatran B01A E07, Rivaroxiban B01A X06, Apixaban B01A F02, Warfarin B01A A03, Apixaban C522181, Rivaroxiban C503223, Dabigatran C554682, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Dabigatran 1037042,
Outcomes
Dabigatran B01A E07, Rivaroxiban B01A X06, Apixaban B01A F02, Warfarin B01A A03, Apixaban C522181, Rivaroxiban C503223, Dabigatran C554682, Warfarin 11289, Warfarin D014859, Warfarin 372756006, Dabigatran 1037042,

PICO 1.6

Population
Kritisk syke LMWH 87233003, LMWH B01A B, LMWH D006495, Placebo D015990,
Intervention
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495, Placebo D015990,
Comparator
Placebo LMWH 87233003, LMWH B01A B, LMWH D006495, Placebo D015990,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495, Placebo D015990,

PICO 1.6

Population
Tromboseprofylakse hos pasienter med høy risiko
Intervention
Kompresjonsstrømper
Comparator
Ingen behandling
Outcomes

PICO 1.7

Population
Akutt iskemisk slag
Intervention
Mekanisk trombektomi
Comparator
Ingen trombektomi
Outcomes

PICO 1.7

Population
Beslutningsstøtte til dosering av warfarin
Intervention
Beslutningsstøtte
Comparator
Manuell dosering
Outcomes

PICO 1.7

Population
Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 0 Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.7

Population
Inneliggende indremedisinske pasienter Apixaban B01A F02, Apixaban C522181, LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Apixaban Apixaban B01A F02, Apixaban C522181, LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
LMWH Apixaban B01A F02, Apixaban C522181, LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
Apixaban B01A F02, Apixaban C522181, LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.7

Population
Tromboseprofylakse hos pasienter med lav risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Mekanisk profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.8

Population
Akutt iskemisk slag Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA <48 timer Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
Ingen ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.8

Population
Optimalt INR-nivå
Intervention
INR > 3
Comparator
INR 2-3
Outcomes

PICO 1.8

Population
Atrieflimmer og moderat risiko for slag: CHA2DS2-VASc 1 Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.8

Population
Indremedisinske pasienter med indikasjon for profylakse
Intervention
Rivaroksaban
Comparator
LMWH
Outcomes

PICO 1.8

Population
Tromboseprofylakse hos pasienter med moderat risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Mekanisk profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.9

Population
Akutt iskemisk slag Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Intervention
Antikoagulantia Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Comparator
Platehemmer Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Outcomes
Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 1.9

Population
Optimalt INR-nivå
Intervention
INR < 2
Comparator
INR 2-3
Outcomes

PICO 1.9

Population
Atrieflimmer og høy risiko for slag: CHA2DS2-VASc 2 eller høyere Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.9

Population
Indremedisinske pasienter med indikasjon for profylakse
Intervention
Rivaroksaban
Comparator
Placebo
Outcomes

PICO 1.9

Population
Tromboseprofylakse hos pasienter med høy risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Mekanisk profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.10

Population
Pasienter med antifosfolipidsyndrom og lav risiko
Intervention
Høy INR
Comparator
Moderat INR
Outcomes

PICO 1.10

Population
Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 0 Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
Warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.10

Population
Tromboseprofylakse hos pasienter med lav risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Heparin + kompresjonsstrømper LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
LMWH eller UFH LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.11

Population
Pasienter med antifosfolipidsyndrom og høy risiko
Intervention
Høy INR
Comparator
Moderat INR
Outcomes

PICO 1.11

Population
Atrieflimmer og moderat risiko for slag: CHA2DS2-VASc 1 Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
Warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.11

Population
Tromboseprofylakse hos pasienter med moderat risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Heparin + kompresjonsstrømper LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
LMWH eller UFH LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.12

Population
Atrieflimmer og høy risiko for slag: CHA2DS2-VASc 2 eller høyere Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
Warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.12

Population
Tromboseprofylakse hos pasienter med høy risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Heparin + kompresjonsstrømper LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
LMWH eller UFH LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.13

Population
Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 0 Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA + klopidogrel Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.13

Population
Tromboseprofylakse hos pasienter med moderat risiko for trombose og høy risiko for blødning LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Mekanisk profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.14

Population
Atrieflimmer og moderat risiko for slag: CHA2DS2-VASc 1 Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA + klopidogrel Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.14

Population
Utvidet profylakse hos høyrisikopasienter, eks. med aktiv malign sykdom
Intervention
Utvidet medikamentell profylakse
Comparator
Kortvarig medikamentell profylakse
Outcomes

PICO 1.15

Population
Atrieflimmer og høy risiko for slag: CHA2DS2-VASc 2 eller høyere
Intervention
ASA + klopidogrel
Comparator
ASA
Outcomes

PICO 1.15

Population
Tromboseprofylakse hos pasienter med høy risiko for trombose og høy risiko for blødning LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Mekanisk profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.16

Population
Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 0
Intervention
Dabigatran 150 mg x 2
Comparator
Warfarin
Outcomes

PICO 1.16

Population
Tromboseprofylakse ved allergi mot hepariner hos pasienter med høy risiko for VT Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.17

Population
Atrieflimmer og moderat risiko for slag: CHA2DS2-VASc 1 Dabigatran B01A E07, Dabigatran 1037042, Dabigatran C554682, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Intervention
Dabigatran 150 mg x 2 Dabigatran B01A E07, Dabigatran 1037042, Dabigatran C554682, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Comparator
Warfarin Dabigatran B01A E07, Dabigatran 1037042, Dabigatran C554682, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Outcomes
Dabigatran B01A E07, Dabigatran 1037042, Dabigatran C554682, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 1.17

Population
Vena cava filter hos høyrisikopasienter, inkludert traumepasienter
Intervention
IVC filter
Comparator
Ingen filter
Outcomes

PICO 1.18

Population
Atrieflimmer og høy risiko for slag: CHA2DS2-VASc 2 eller høyere
Intervention
Dabigatran 150 mg x 2
Comparator
Warfarin
Outcomes

PICO 1.18

Population
Tromboseprofylakse hos pasienter med høy risiko for VT og lav blødningsrisiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Fondaparinuks LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 1.19

Population
Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 0
Intervention
Dabigatran 110 mg x 2
Comparator
Warfarin
Outcomes

PICO 1.20

Population
Atrieflimmer og moderat risiko for slag: CHA2DS2-VASc 1
Intervention
Dabigatran 110 mg x 2
Comparator
Warfarin
Outcomes

PICO 1.21

Population
Atrieflimmer og høy risiko for slag: CHA2DS2-VASc 2 eller høyere
Intervention
Dabigatran 110 mg x 2
Comparator
Warfarin
Outcomes

PICO 1.22

Population
Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 0
Intervention
Apixaban
Comparator
Warfarin
Outcomes

PICO 1.23

Population
Atrieflimmer og moderat risiko for slag: CHA2DS2-VASc 1
Intervention
Apixaban
Comparator
Warfarin
Outcomes

PICO 1.24

Population
Atrieflimmer og høy risiko for slag: CHA2DS2-VASc 2 eller høyere
Intervention
Apixaban
Comparator
Warfarin
Outcomes

PICO 1.25

Population
Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 0
Intervention
Rivaroksaban
Comparator
Warfarin
Outcomes

PICO 1.26

Population
Atrieflimmer og moderat risiko for slag: CHA2DS2-VASc 1
Intervention
Rivaroksaban
Comparator
Warfarin
Outcomes

PICO 1.27

Population
Atrieflimmer og høy risiko for slag: CHA2DS2-VASc 2 eller høyere
Intervention
Rivaroksaban
Comparator
Warfarin
Outcomes

PICO 1.28

Population
Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 0 Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
Apixaban Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 1.29

Population
Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 1 Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Clopidogrel 32968, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 108979001, Aspirin 387458008,
Intervention
Apixaban Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Clopidogrel 32968, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 108979001, Aspirin 387458008,
Comparator
ASA Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Clopidogrel 32968, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 108979001, Aspirin 387458008,
Outcomes
Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Clopidogrel 32968, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 108979001, Aspirin 387458008,

PICO 1.30

Population
Atrieflimmer og lav risiko for slag: CHA2DS2-VASc 2 eller høyere Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 108979001, Aspirin 387458008,
Intervention
Apixaban Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 108979001, Aspirin 387458008,
Comparator
ASA Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 108979001, Aspirin 387458008,
Outcomes
Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 108979001, Aspirin 387458008,

PICO 2.1

Population
Symptomatisk PAD Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 2.1

Population
Akutt VT LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Parenteral antikoagulasjon LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 2.1

Population
Tromboseprofylakse ved nedsatt bevegelighet LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
LMWH/UFH LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 2.1

Population
Etablert koronarsykdom Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin 1191, Clopidogrel 32968, cardiovascular disease D002318, Clopidogrel C055162, Aspirin D001241, Aspirin D001241,
Intervention
Klopidogrel og ASA Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin 1191, Clopidogrel 32968, cardiovascular disease D002318, Clopidogrel C055162, Aspirin D001241, Aspirin D001241,
Comparator
ASA Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin 1191, Clopidogrel 32968, cardiovascular disease D002318, Clopidogrel C055162, Aspirin D001241, Aspirin D001241,
Outcomes
Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin 1191, Clopidogrel 32968, cardiovascular disease D002318, Clopidogrel C055162, Aspirin D001241, Aspirin D001241,

PICO 2.1

Population
Elektiv, ikke-kardial kirurgi hos pasienter med lav kardiovaskulær risiko
Intervention
Kontinuere platehemmer
Comparator
Stoppe platehemmer 7-10 dager preoperativt
Outcomes

PICO 2.1

Population
Tromboseprofylakse ved hofte- og kneprotese LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Heparin LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 2.1

Population
Antikoagulasjon før konvertering
Intervention
TØE + forkortet antikoagulasjon
Comparator
Antikoagulasjon > 3 uker
Outcomes

PICO 2.1

Population
Langtidsbehandling av DVT og lungeemboli hos gravide LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Intervention
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Comparator
Vitamin K antagonist LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 2.2

Population
Symptomatisk PAD Clopidogrel 108979001, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
Klopidogrel Clopidogrel 108979001, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Clopidogrel 108979001, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Clopidogrel 108979001, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 2.2

Population
Tromboseprofylakse ved nedsatt bevegelighet LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
UFH LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 2.2

Population
Etablert koronarsykdom Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Warfarin 372756006, Aspirin 387458008, cardiovascular disease 49601007, Aspirin B01 AC06, Warfarin B01A A03, Aspirin B01 AC06, Aspirin 1191, Warfarin 11289, Aspirin 1191, Aspirin D001241, Warfarin D014859, Aspirin D001241, cardiovascular disease D002318,
Intervention
Warfarin og ASA Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Warfarin 372756006, Aspirin 387458008, cardiovascular disease 49601007, Aspirin B01 AC06, Warfarin B01A A03, Aspirin B01 AC06, Aspirin 1191, Warfarin 11289, Aspirin 1191, Aspirin D001241, Warfarin D014859, Aspirin D001241, cardiovascular disease D002318,
Comparator
ASA Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Warfarin 372756006, Aspirin 387458008, cardiovascular disease 49601007, Aspirin B01 AC06, Warfarin B01A A03, Aspirin B01 AC06, Aspirin 1191, Warfarin 11289, Aspirin 1191, Aspirin D001241, Warfarin D014859, Aspirin D001241, cardiovascular disease D002318,
Outcomes
Chronic cardiovascular disease I25, cardiovascular disease I51.6, Angina Pectoris I20, STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Other acute cardiovascular disease I24, Aspirin 387458008, Warfarin 372756006, Aspirin 387458008, cardiovascular disease 49601007, Aspirin B01 AC06, Warfarin B01A A03, Aspirin B01 AC06, Aspirin 1191, Warfarin 11289, Aspirin 1191, Aspirin D001241, Warfarin D014859, Aspirin D001241, cardiovascular disease D002318,

PICO 2.2

Population
Elektiv, ikke-kardial kirurgi hos pasienter med moderat-høy kardiovaskulær risiko
Intervention
Kontinuere platehemmer
Comparator
Stoppe platehemmer 7-10 dager preoperativt
Outcomes

PICO 2.3

Population
Symptomatisk PAD Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA + klopidogrel Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 2.3

Population
Akutt VT LMWH 87233003, LMWH B01A B, LMWH D006495, LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
LMWH en gang daglig LMWH 87233003, LMWH B01A B, LMWH D006495, LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
LMWH to ganger daglig LMWH 87233003, LMWH B01A B, LMWH D006495, LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495, LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 2.3

Population
Tromboseprofylakse ved nedsatt bevegelighet
Intervention
Kompresjonsstrømper
Comparator
Ingen strømper
Outcomes

PICO 2.3

Population
Pasienter med malign sykdom og samtidig CVK
Intervention
Heparin
Comparator
Ingen antikoagulasjon
Outcomes

PICO 2.4

Population
Symptomatisk PAD Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
Warfarin + ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 2.4

Population
Tromboseprofylakse ved hjerneblødning og nedsatt bevegelighet
Intervention
LMWH/UFH
Comparator
Ingen profylakse
Outcomes

PICO 2.4

Population
Pasienter med malign kreftsykdom, men uten andre indikasjoner for antikoagulasjon
Intervention
Heparin
Comparator
Ingen antikoagulasjon
Outcomes

PICO 2.5

Population
Langtidsbehandling hos pasienter uten kreft LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Intervention
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Comparator
Warfarin LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 2.5

Population
Tromboseprofylakse ved hjerneblødning og nedsatt bevegelighet
Intervention
Tidlig profylakse (dag 2-4)
Comparator
Sen profylakse
Outcomes

PICO 2.5

Population
Pasienter med malign kreftsykdom, men uten andre indikasjoner for antikoagulasjon
Intervention
Peroral antikoagulasjon
Comparator
Ingen antikoagulasjon
Outcomes

PICO 2.6

Population
Langtidsbehandling hos pasienter med ikke-metastasert kreft LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Intervention
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Comparator
Warfarin LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 2.6

Population
Polikliniske kreftpasienter under pågående cytostatikabehandling
Intervention
LMWH
Comparator
Placebo
Outcomes

PICO 2.7

Population
Langtidsbehandling hos pasienter med metastasert kreft LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Intervention
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Comparator
Warfarin LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 2.8

Population
Akutt og langtidsbehandling Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Intervention
Rivaroksaban Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Comparator
Warfarin+LMWH Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Outcomes
Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,

PICO 2.8

Population
Tromboseprofylakse ved hoftefraktur LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Heparin LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 2.9

Population
Utvidet behandling Rivaroxiban B01A X06, Rivaroxiban C503223, Placebo D015990,
Intervention
Rivaroksaban Rivaroxiban B01A X06, Rivaroxiban C503223, Placebo D015990,
Comparator
Placebo Rivaroxiban B01A X06, Rivaroxiban C503223, Placebo D015990,
Outcomes
Rivaroxiban B01A X06, Rivaroxiban C503223, Placebo D015990,

PICO 2.10

Population
Langtidsbehandling Dabigatran B01A E07, Dabigatran 1037042, Dabigatran C554682, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Intervention
Dabigatran Dabigatran B01A E07, Dabigatran 1037042, Dabigatran C554682, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Comparator
Warfarin Dabigatran B01A E07, Dabigatran 1037042, Dabigatran C554682, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,
Outcomes
Dabigatran B01A E07, Dabigatran 1037042, Dabigatran C554682, Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859,

PICO 2.11

Population
Langtidsbehandling Rivaroxiban B01A X06, Dabigatran B01A E07, Dabigatran 1037042, Rivaroxiban C503223, Dabigatran C554682, Warfarin D014859, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006,
Intervention
Rivaroksaban eller dabigatran Rivaroxiban B01A X06, Dabigatran B01A E07, Dabigatran 1037042, Rivaroxiban C503223, Dabigatran C554682, Warfarin D014859, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006,
Comparator
Warfarin Rivaroxiban B01A X06, Dabigatran B01A E07, Dabigatran 1037042, Rivaroxiban C503223, Dabigatran C554682, Warfarin D014859, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006,
Outcomes
Rivaroxiban B01A X06, Dabigatran B01A E07, Dabigatran 1037042, Rivaroxiban C503223, Dabigatran C554682, Warfarin D014859, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006,

PICO 2.11

Population
Tromboseprofylakse ved hofte- eller kneprotese Dabigatran B01A E07, Apixaban B01A F02, Rivaroxiban B01A X06, Dabigatran 1037042, Dabigatran C554682, Apixaban C522181, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Nye perorale antikoagulantia Dabigatran B01A E07, Apixaban B01A F02, Rivaroxiban B01A X06, Dabigatran 1037042, Dabigatran C554682, Apixaban C522181, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
LMWH Dabigatran B01A E07, Apixaban B01A F02, Rivaroxiban B01A X06, Dabigatran 1037042, Dabigatran C554682, Apixaban C522181, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
Dabigatran B01A E07, Apixaban B01A F02, Rivaroxiban B01A X06, Dabigatran 1037042, Dabigatran C554682, Apixaban C522181, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 2.12

Population
Forebygging av posttrombotisk syndrom
Intervention
Kompresjonsstrømper
Comparator
Ingen strømper
Outcomes

PICO 2.12

Population
Tromboseprofylakse hos pasienter med høy risiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Heparin LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 2.13

Population
Akutt DVT i benet
Intervention
Tidlig mobilisering
Comparator
Sen mobilisering
Outcomes

PICO 2.13

Population
Tromboseprofylakse hos pasienter med moderat risiko LMWH D006495, LMWH B01A B, LMWH 87233003,
Intervention
Heparin LMWH D006495, LMWH B01A B, LMWH 87233003,
Comparator
Ingen profylakse LMWH D006495, LMWH B01A B, LMWH 87233003,
Outcomes
LMWH D006495, LMWH B01A B, LMWH 87233003,

PICO 2.14

Population
Akutt DVT i benet
Intervention
Behandling hjemme
Comparator
Behandling på sykehus
Outcomes

PICO 2.14

Population
Tromboseprofylakse ved fast-track kirurgi
Intervention
Heparin
Comparator
Ingen profylakse
Outcomes

PICO 2.15

Population
Akutt lungeemboli
Intervention
Tidlig utskrivning
Comparator
Standard utskrivning
Outcomes

PICO 2.16

Population
DVT og lungeemboli Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Intervention
Apixaban Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Comparator
Warfarin+enoxaparin Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Outcomes
Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,

PICO 2.17

Population
Utvidet behandling av DVT og lungeemboli Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Intervention
Apixaban 2.5 mg x 2 Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Comparator
Placebo Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Outcomes
Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,

PICO 2.18

Population
Utvidet behandling av DVT og lungeemboli Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Intervention
Apixaban 5 mg x 2 Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Comparator
Placebo Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Outcomes
Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,

PICO 2.19

Population
Utvidet behandling av DVT og lungeemboli Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Intervention
Apixaban 2.5 mg x 2 Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Comparator
Apixaban 5 mg x 2 Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,
Outcomes
Rivaroxiban B01A X06, Rivaroxiban C503223, LMWH 87233003, LMWH B01A B, Warfarin 11289, Warfarin B01A A03, Warfarin 372756006, LMWH D006495, Warfarin D014859,

PICO 3.1

Population
Symptomatisk PAD og klaudicatio LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Hepariner LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 3.1

Population
Sekundærprevensjon ved ikke-kardioembolisk iskemis hjerneslag eller TIA
Intervention
Antikoagulantia
Comparator
Platehemmer
Outcomes

PICO 3.1

Population
Første året etter akutt koronarsyndrom STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Intervention
Klopidogrel STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Comparator
ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Outcomes
STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,

PICO 3.1

Population
Tromboseprofylakse ved kneartroskopi LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Heparin LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 3.1

Population
Blødningsrisiko ved behandling med enoxaparin og nyresvikt
Intervention
Blødning ved clearance < 30
Comparator
Blødning ved clearance >30
Outcomes

PICO 3.1

Population
Atrieflimmer, lav risiko for slag (CHA2DS2-VASc 0) og koronarsykom etter PCI med stent
Intervention
Warfarin+klopidogrel+ASA
Comparator
Klopidogrel+ASA
Outcomes

PICO 3.1

Population
Passasjerer på langdistansefly, lav risiko
Intervention
Kompresjonsstrømper
Comparator
Ingen strømper
Outcomes

PICO 3.2

Population
Klaudikatio intermittens
Intervention
Prostaglandiner
Comparator
Ingen behandling
Outcomes

PICO 3.2

Population
Første året etter akutt koronarsyndrom STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, cardiovascular disease D002318,
Intervention
Klopidogrel og ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, cardiovascular disease D002318,
Comparator
ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, cardiovascular disease D002318,
Outcomes
STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, cardiovascular disease D002318,

PICO 3.2

Population
Tromboseprofylakse ved underekstremitetsskade LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Heparin LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 3.2

Population
Behandling med UFH
Intervention
Vektjustert dosering
Comparator
Fast dosering
Outcomes

PICO 3.2

Population
Atrieflimmer, moderat risiko for slag (CHA2DS2-VASc 1) og koronarsykom etter PCI med stent Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Warfarin D014859, Clopidogrel C055162, Aspirin D001241, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
Intervention
Warfarin+klopidogrel+ASA Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Warfarin D014859, Clopidogrel C055162, Aspirin D001241, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
Comparator
Klopidogrel+ASA Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Warfarin D014859, Clopidogrel C055162, Aspirin D001241, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
Outcomes
Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Warfarin D014859, Clopidogrel C055162, Aspirin D001241, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,

PICO 3.2

Population
Asymptomatisk trombofili Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 3.3

Population
Kritisk iskemi
Intervention
Prostanoider
Comparator
Placebo
Outcomes

PICO 3.3

Population
Første året etter akutt koronarsyndrom STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Intervention
Ticagrelor og ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Comparator
Klopidogrel og ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Outcomes
STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,

PICO 3.3

Population
Screening av DVT
Intervention
Rutinemessig UL før utskrivelse
Comparator
Ingen screening
Outcomes

PICO 3.3

Population
Atrieflimmer, høy risiko for slag (CHA2DS2-VASc 2 eller høyere) og koronarsykom etter PCI med stent Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Warfarin B01A A03, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Aspirin D001241, Clopidogrel C055162, Warfarin D014859, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
Intervention
Warfarin+klopidogrel+ASA Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Warfarin B01A A03, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Aspirin D001241, Clopidogrel C055162, Warfarin D014859, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
Comparator
Klopidogrel+ASA Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Warfarin B01A A03, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Aspirin D001241, Clopidogrel C055162, Warfarin D014859, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
Outcomes
Warfarin 372756006, Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Warfarin B01A A03, Aspirin 1191, Clopidogrel 32968, Warfarin 11289, Aspirin D001241, Clopidogrel C055162, Warfarin D014859, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,

PICO 3.4

Population
Akutt iskemi
Intervention
Trombolyse
Comparator
Kirurgi
Outcomes

PICO 3.4

Population
Første året etter akutt koronarsyndrom med PCI STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Intervention
Prasugrel og ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Comparator
Klopidogrel og ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Outcomes
STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,

PICO 3.5

Population
Første året etter akutt koronarsyndrom, medikamentelt behandlet STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Intervention
Prasugrel og ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Comparator
Klopidogrel og ASA STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Outcomes
STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,

PICO 3.6

Population
Første året etter akutt koronarsyndrom STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Intervention
Rivaroksaban 2,5 mg x 2 STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Comparator
Placebo STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Outcomes
STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,

PICO 3.7

Population
Første året etter akutt koronarsyndrom STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Intervention
Rivaroksaban 5 mg x 2 STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Comparator
Placebo STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,
Outcomes
STEMI and NSTEMI 1. I21, STEMI and NSTEMI 2. I22, Clopidogrel 108979001, Aspirin 387458008, Clopidogrel B01A C04, Aspirin B01 AC06, Clopidogrel 32968, Aspirin 1191, Clopidogrel C055162, Aspirin D001241, cardiovascular disease D002318,

PICO 4.1

Population
Symptomatisk PAD Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
Intervention
ASA + klopidogrel Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
Comparator
ASA Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
Outcomes
Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,

PICO 4.1

Population
Behandlingslengde
Intervention
6-12 mnd
Comparator
3 mnd
Outcomes

PICO 4.1

Population
Sinusvenetrombose
Intervention
Antikoagulasjon
Comparator
Ingen behandling
Outcomes

PICO 4.1

Population
Elektiv PCI med DES Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,
Intervention
19mnd klopidogrel og ASA Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,
Comparator
12mnd klopidogrel og ASA Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,
Outcomes
Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,

PICO 4.1

Population
Høy INR (4.5-10) og ingen blødning
Intervention
Vitamin K
Comparator
Stoppe warfarin
Outcomes

PICO 4.1

Population
Tromboseprofylakse ved assistert befruktning
Intervention
LMVH
Comparator
Ingen behandling
Outcomes

PICO 4.1

Population
Mekanisk profylakse (IPCD) hos kraniotomerte
Intervention
Intermittent Compression Device
Comparator
Ingen profylakse
Outcomes

PICO 4.2

Population
Akutt koronarsykdom Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA + klopidogrel Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 4.2

Population
Behandlingslengde
Intervention
4 eller 6 uker
Comparator
3 eller 6 mnd
Outcomes

PICO 4.2

Population
Elektiv PCI med BMS Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
Intervention
6-12mnd klopidogrel og ASA Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
Comparator
1mnd klopidogrel og ASA Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,
Outcomes
Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin B01 AC06, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162,

PICO 4.2

Population
Tromboseprofylakse ved OHSS
Intervention
LMVH
Comparator
Ingen behandling
Outcomes

PICO 4.2

Population
Mekanisk profylakse hos kraniotomerte
Intervention
Intermittent Compression Device
Comparator
Kompresjonsstrømper
Outcomes

PICO 4.3

Population
Fremreveggsinfarkt med venstre ventrikkeltrombe
Intervention
Warfarin, ASA og klopidogrel
Comparator
Klopidogrel og ASA
Outcomes

PICO 4.3

Population
Tromboseprofylakse ved tidligere tromboemboli: Lav risiko
Intervention
LMVH
Comparator
Ingen behandling
Outcomes

PICO 4.3

Population
Tromboseprofylakse hos kraniotomerte LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen behandling LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 4.4

Population
Elektiv PCI med DES Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,
Intervention
Kortvarig behandling med ASA+klopidogrel Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,
Comparator
Langvarig behandling med ASA + klopidogrel Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,
Outcomes
Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Clopidogrel C055162, Aspirin D001241, Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Clopidogrel 32968, Aspirin 1191, Aspirin D001241, Clopidogrel C055162,

PICO 4.4

Population
Tromboseprofylakse ved tidligere tromboemboli: Moderat-høy risiko
Intervention
LMVH
Comparator
Ingen behandling
Outcomes

PICO 4.4

Population
Mekanisk (IPCD) + medikamentell profylakse hos kraniotomerte
Intervention
IPCD + heparin
Comparator
IPCD
Outcomes

PICO 4.5

Population
Tromboseprofylakse ved homozygot f. V Leiden og protrombin 20210A mutasjon
Intervention
LMVH
Comparator
Ingen behandling
Outcomes

PICO 4.5

Population
Tromboseprofylakse ved spinalkirurgi: Lav risiko
Intervention
Kompresjonsstrømper
Comparator
Ingen profylakse
Outcomes

PICO 4.6

Population
Tromboprofylakse ved heterozygot faktor V Leiden og protrombin 20210A mutasjon og familieanamnese, kombinasjon Leiden og protrombin
Intervention
LMVH
Comparator
Ingen behandling
Outcomes

PICO 4.6

Population
Tromboseprofylakse ved spinalkirurgi: Moderat risiko
Intervention
Kompresjonsstrømper
Comparator
Ingen profylakse
Outcomes

PICO 4.7

Population
Tromboseprofylakse ved antitrombinmagnel med eller uten familieanamnese
Intervention
LMVH
Comparator
Ingen behandling
Outcomes

PICO 4.7

Population
Tromboseprofylakse ved spinalkirurgi: Høy risiko
Intervention
Kompresjonsstrømper
Comparator
Ingen profylakse
Outcomes

PICO 4.8

Population
Tromboprofylakse ved protein C og S mangel og familieanamnese
Intervention
LMVH
Comparator
Ingen behandling
Outcomes

PICO 4.8

Population
Tromboseprofylakse ved spinalkirurgi: Moderat risiko
Intervention
LMWH
Comparator
Ingen profylakse
Outcomes

PICO 4.9

Population
Tromboseprofylakse ved keisersnitt hos gravide med lav risiko
Intervention
LMVH
Comparator
Ingen behandling
Outcomes

PICO 4.9

Population
Tromboseprofylakse ved spinalkirurgi: Høy risiko
Intervention
LMWH
Comparator
Ingen profylakse
Outcomes

PICO 4.10

Population
Tromboseprofylakse ved keisersnitt hos gravide med høy risiko
Intervention
LMVH
Comparator
Ingen behandling
Outcomes

PICO 4.11

Population
Tromboseprofylakse ved keisersnitt hos gravide med moderat risiko
Intervention
LMVH
Comparator
Ingen behandling
Outcomes

PICO 4.12

Population
Tromboseprofylakse ved keisersnitt hos gravide med svært høy risiko
Intervention
LMVH
Comparator
Ingen behandling
Outcomes

PICO 5.1

Population
Perifer bypass Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA + dipyridamol Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 5.1

Population
Postoperativ proksimal DVT eller lungeemboli
Intervention
Forlenget antikoagulasjon
Comparator
Kortvarig antikoagulasjon
Outcomes

PICO 5.1

Population
Første mnd etter PCI Warfarin 372756006, Aspirin 387458008, Aspirin B01 AC06, Warfarin B01A A03, Aspirin 1191, Warfarin 11289, Aspirin D001241, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
Intervention
Thienopyridine og ASA Warfarin 372756006, Aspirin 387458008, Aspirin B01 AC06, Warfarin B01A A03, Aspirin 1191, Warfarin 11289, Aspirin D001241, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
Comparator
Warfarin og ASA Warfarin 372756006, Aspirin 387458008, Aspirin B01 AC06, Warfarin B01A A03, Aspirin 1191, Warfarin 11289, Aspirin D001241, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
Outcomes
Warfarin 372756006, Aspirin 387458008, Aspirin B01 AC06, Warfarin B01A A03, Aspirin 1191, Warfarin 11289, Aspirin D001241, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,

PICO 5.2

Population
Perifer bypass Aspirin 387458008, Aspirin B01 AC06, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA + klopidogrel Aspirin 387458008, Aspirin B01 AC06, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Aspirin 387458008, Aspirin B01 AC06, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Clopidogrel 108979001, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 5.2

Population
Førstegangs-VT utløst av forbigående, ikke-kirurgisk risikofaktor med høy blødningsrisiko
Intervention
Forlenget antikoagulasjon
Comparator
Kortvarig antikoagulasjon
Outcomes

PICO 5.2

Population
Tromboseprofylakse ved traumekirurgi hos pasienter med lav tromboserisiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 5.3

Population
Kunstgraft under kneet Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
Intervention
ASA + klopidogrel Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
Comparator
ASA Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
Outcomes
Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Clopidogrel B01A C04, Aspirin 1191, Clopidogrel 32968, Aspirin D001241, Clopidogrel C055162, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,

PICO 5.3

Population
Førstegangs-VT utløst av forbigående, ikke-kirurgisk risikofaktor med lav-moderat blødningsrisiko
Intervention
Forlenget antikoagulasjon
Comparator
Kortvarig antikoagulasjon
Outcomes

PICO 5.3

Population
Tromboseprofylakse ved traumekirurgi hos pasienter med høy tromboserisiko LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
LMWH LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Ingen profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 5.4

Population
Kirurgisk revaskularisering Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
Warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 5.4

Population
Førstegangs spontan trombose med lav-moderat blødningsrisiko
Intervention
Forlenget antikoagulasjon
Comparator
Kortvarig antikoagulasjon
Outcomes

PICO 5.4

Population
Tromboseprofylakse ved traumekirurgi
Intervention
Kompresjonsstrømper
Comparator
Ingen profylakse
Outcomes

PICO 5.5

Population
Venegraft til leggearterie Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
Warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 5.5

Population
Førstegangs spontan trombose med høy blødningsrisiko
Intervention
Forlenget antikoagulasjon
Comparator
Kortvarig antikoagulasjon
Outcomes

PICO 5.5

Population
Tromboseprofylakse ved traumekirurgi LMWH 87233003, LMWH B01A B, LMWH D006495,
Intervention
Mekanisk + medikamentell profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Comparator
Medikamentell profylakse LMWH 87233003, LMWH B01A B, LMWH D006495,
Outcomes
LMWH 87233003, LMWH B01A B, LMWH D006495,

PICO 5.6

Population
Annengangs spontan trombose med lav blødningsrisiko
Intervention
Forlenget antikoagulasjon
Comparator
Kortvarig antikoagulasjon
Outcomes

PICO 5.7

Population
Annengangs spontan trombose med moderat-høy blødningsrisiko
Intervention
Forlenget antikoagulasjon
Comparator
Kortvarig antikoagulasjon
Outcomes

PICO 5.8

Population
Førstegangs spontan trombose med lav-moderat blødningsrisiko
Intervention
ASA som langtidsprofylakse
Comparator
Ingen behandling
Outcomes

PICO 6.1

Population
Sekundær prevensjon etter TIA/slag Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 6.1

Population
Systolisk dysfunksjon av venstre ventrikkel Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
Intervention
Warfarin Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
Comparator
ASA Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,
Outcomes
Warfarin 372756006, Warfarin B01A A03, Warfarin 11289, Warfarin D014859, Aspirin D001241, Aspirin 1191, Aspirin B01 AC06, Aspirin 387458008,

PICO 6.1

Population
Profylakse ved antifosfolipidsyndrom og habituelle aborter Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
UFH + ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 6.2

Population
Sekundær prevensjon etter TIA/slag Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162,
Intervention
Klopidogrel Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162,
Comparator
ASA Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162,
Outcomes
Clopidogrel 108979001, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04, Clopidogrel 32968, Clopidogrel C055162,

PICO 6.2

Population
DVT i underekstremitet
Intervention
Systemisk trombolyse
Comparator
Standard antikoagulasjon
Outcomes

PICO 6.2

Population
Profylakse ved habituell abort uten kjent trombofili Aspirin 387458008, LMWH 87233003, Aspirin B01 AC06, LMWH B01A B, Aspirin 1191, Aspirin D001241, LMWH D006495,
Intervention
LMWH + ASA Aspirin 387458008, LMWH 87233003, Aspirin B01 AC06, LMWH B01A B, Aspirin 1191, Aspirin D001241, LMWH D006495,
Comparator
Ingen behandling Aspirin 387458008, LMWH 87233003, Aspirin B01 AC06, LMWH B01A B, Aspirin 1191, Aspirin D001241, LMWH D006495,
Outcomes
Aspirin 387458008, LMWH 87233003, Aspirin B01 AC06, LMWH B01A B, Aspirin 1191, Aspirin D001241, LMWH D006495,

PICO 6.3

Population
Sekundær prevensjon etter TIA/slag Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA + dipyridamol Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 6.3

Population
Akutt lungeemboli, lav risiko
Intervention
Systemisk trombolyse
Comparator
Standard antikoagulasjon
Outcomes

PICO 6.3

Population
Profylakse mot preeklampsi hos gravide uten kjent trombofili Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 6.4

Population
Sekundær prevensjon etter TIA/slag
Intervention
ASA + dipyridamol
Comparator
Klopidogrel
Outcomes

PICO 6.4

Population
Akutt lungeemboli, høy risiko
Intervention
Systemisk trombolyse
Comparator
Standard antikoagulasjon
Outcomes

PICO 6.4

Population
Profylakse ved habituell abort uten kjent trombofili Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Intervention
ASA Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Comparator
Ingen behandling Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,
Outcomes
Aspirin 387458008, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241,

PICO 6.5

Population
Sekundær prevensjon etter TIA/slag Aspirin 387458008, Clopidogrel 108979001, Aspirin B01 AC06, Aspirin 1191, Aspirin D001241, Clopidogrel B01A C04,